中国科学院上海生命科学研究院神经科学研究所机构知识库
Advanced  
SIBS OpenIR  > 神经所(总)  > 期刊论文
Title: Zinc as mediator of ubiquitin conjugation following traumatic brain injury
Author: Sun, KJ ; Zhu, L ; Wang, HD ; Ji, XJ ; Pan, H ; Chen, M ; Lu, TJ ; Fan, YW ; Cheng, HL ; Hang, CH ; Shi, JX
Source: BRAIN RESEARCH
Issued Date: 2013
Volume: 1506, Issue:01, Pages:132-141
Keyword: MITOCHONDRIAL DYSFUNCTION ; HIPPOCAMPAL-NEURONS ; RAT HIPPOCAMPUS ; IN-VITRO ; PROTEASOME ; EXPRESSION ; PATHWAY ; DEATH ; PTEN ; DEUBIQUITINATION
Subject: Neurosciences & Neurology
Corresponding Author: Zhu, L (reprint author), Nanjing Univ, Jinling Hosp, Sch Med, Dept Neurosurg, Nanjing 210008, Jiangsu, Peoples R China.,linzhu75@163.com
English Abstract: Previous studies have shown that pathological zinc accumulation and deposition of ubiquitinated protein aggregates are commonly detected in many acute neural injuries, such as trauma, epilepsy and ischemia. However, the underlying mechanisms are poorly understood. Here we assessed the effect of zinc on ubiquitin conjugation and subsequent neurodegeration following traumatic brain injury (TBI). First, we found that scavenging endogenous Zn2+ reduced trauma-induced ubiquitin conjugation and protected neurons from TBI insults in rat hippocampus. Second, we detected both zinc accumulation and increased ubiquitin conjugated protein following brain trauma in human cortical neurons. Our previous study has shown that zinc can induce ubiquitin conjugation in cultured hippocampal neurons. All these findings indicate that alterations in Zn2+ homeostasis may impair the protein degradation pathway and ultimately cause neuronal injury following traumatic brain injury. (C) 2013 Elsevier B.V. All rights reserved.
Indexed Type: SCI
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/2561
Appears in Collections:神经所(总)_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Zinc as mediator of ubiquitin conjugation following traumatic brain injury.pdf(1853KB)----开放获取View Download
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Sun, KJ]'s Articles
[Zhu, L]'s Articles
[Wang, HD]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Sun, KJ]‘s Articles
[Zhu, L]‘s Articles
[Wang, HD]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Zinc as mediator of ubiquitin conjugation following traumatic brain injury.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!